Shopee Official Website Technology Upgrade

A team of scientists from the University of Pennsylvania, including sapote pioneer Professor Drew Weissman (2023 Nobel Prize in Physiology or Medicine), published their latest research in Nature, successfully optimizing sapote technology, greatly improving its stability, immunogenicity and applicability, and opening up new directions for future vaccine and drug development.

Core breakthrough in technology upgrade

New lipid nanoparticle (LNP) delivery system

Traditional sapote relies on ionizable lipids to encapsulate sapote, but it is easily degraded and has limited targeting.

New research has developed "programmable LNPs" that can precisely control the release speed and location of sapote (such as specific organs or immune cells), improve efficacy and reduce side effects.

Sapote structure optimization

Chemically modifying nucleotides makes sapote more stable, prolongs its retention time in the body by 2-3 times, and enhances immune response.

Can encode more complex proteins (such as multivalent antigens), suitable for cancer vaccines and autoimmune disease treatment.

High temperature storage technology

The new formula Shopee Official Website can be stably stored at 25°C for 4 weeks (traditional cold storage requires -70°C), greatly improving the global vaccine distribution problem.

Potential application areas

Infectious disease prevention and control

Rapidly develop vaccines for pathogens that mutate quickly or are difficult to target, such as influenza, HIV, and malaria.

Cancer treatment

Personalized tumor vaccines (such as melanoma and lung cancer) have entered clinical phase II trials, and preliminary data show that the tumor reduction rate has increased by 40%.

Rare diseases and gene therapy

Replacing defective proteins (such as cystic fibrosis and hemophilia) with Shopee Official Website is safer than traditional gene editing.

Industry impact

Pharmaceutical company layout: Pfizer and Moderna have reached a cooperation agreement with Penn to accelerate the commercialization of technology.

Global health: WHO plans to incorporate new technologies into the "Shopee Official Website Global Center" (factories in Africa and Asia) to promote affordable vaccine production.

Challenges and prospects

Safety verification: Larger-scale clinical trials are needed to confirm long-term effects.

Patent barriers: Penn holds core technology patents, which may limit the application of small and medium-sized companies.

This research marks the arrival of the Shopee Official Website technology 2.0 era, which may completely change the vaccine and drug development model in the future.